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By contrast, the present review seeks to provide an updated and integrative perspective by combining epidemiological evidence with mechanistic insights into airway inflammation, alveolar macrophage dysfunction, and carcinogen-mediated DNA damage

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Together, these trees form a genome-wide genealogical record that underpins downstream analyses, providing the framework for estimating coalescence times, detecting selective sweeps and accounting for genetic relatedness in the genome-wide association study (GWAS) 38

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